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KMID : 0390020080180020138
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Pediatric Allergy and Respiratory Disease
2008 Volume.18 No. 2 p.138 ~ p.147
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The Risk Factors for Persistence of Asthma Symptoms from Late Childhood to Early Adult Life : The Effect of Pulmonary Function and Bronchial Hyperresponsiveness
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Park Jong-Jin
Kang Im-Ju
Kim Jae-Jin
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Abstract
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Purpose: We performed this study to evaluate the effect of pulmonary function and bronchial hyperresponsiveness (BHR) on the persistence of asthma symptoms from late childhood to early adult life.
Methods: One-hundred thirty-one children with asthma treated at our hospital during the past 10 years were divided into 2 groups according to the persistence of symptoms in early adult life: the persistent and remission groups. Information about symptoms, body mass index, serum ECP, serum IgE and skin test reactivity in late childhood were obtained and prebronchodilator FEV1, FEV1/FVC (expressed as % of predicted) and BHR to methacholine were measured in late childhood and early adult life, and compared the 2 groups.
Results: The persistent group was accounted for 45.8% of the subjects and FEV(1), FEV(1)/ FVC and BHR to methacholine in late childhood were associated with the persistence of symptoms. We found a positive correlation between FEV(1) in late childhood and early adult.(r=0.250, P=0.013) Also we found a positive correlation between FEV(1)/FVC in late childhood and early adult.(r=0.285, P=0.018) BHR and FEV1% of 60% to 79% of late childhood were associated with BHR in early adult.(Odds ratio; 95% confidence interval=3.8; 1.7-8.7, 4.6; 1.0-20.2)
Conclusion: Low pulmonary function and increased BHR in childhood asthma were associated with persistence of symptom, degree of pulmonary function and BHR in early adult life.
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KEYWORD
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Pulmonary Function, Bronchial hyperreactivity, Asthma
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